In considering why humans get cancer, it is useful to ask an alternative question, “Why have humans been so good at not getting cancer in the first 4-5 decades of life?” There is no singular explanation for why an aging body is more susceptible to cancer. However, many recent studies now show that aging — and more specifically “inflammaging” — can dramatically drive chronic inflammation, leading to tumor initiation and progression, metastasis, and may influence response to therapies. This cutting-edge symposium will provide up-to-date perspectives on the recent advances in understanding of cancer-related inflammaging, including cellular senescence in cancer and associated predictive and prognostic biomarkers.